top of page

Taking the Mystery Out of Prostate Cancer

Taking the Mystery Out of Prostate Cancer

A diagnosis of prostate cancer is not a death sentence. It may strike fear in the heart of a man when he hears those words, but current statistics can help dispel that fear. Prostate cancer often grows slowly (1), so in many cases, there is time to get a second opinion and formulate a plan. However, even if you do get a diagnosis of prostate cancer, the chances are it will be a slow-growing variety, and your doctor may encourage you to adopt “watchful waiting” (2).


However, the best case scenario is to take action to prevent prostate cancer (or any cancer) from happening in the first place. We highly encourage a proactive approach to reduce your risk of any cancer, as detailed in our article, “Can We Prevent Cancer?” This article will not repeat that information but will instead focus on some details specific to prostate cancer; healing paths that functional medicine can offer for prevention, complementary therapies during treatment, and post-treatment strategies.


The Prostate: The Little Gland with a Big Impact


The prostate is a small gland that is part of the male reproductive system. It lives below the bladder and wraps around the urethra, which is the tube leading from the bladder and out of the penis. The prostate’s function is to produce a fluid that carries sperm out of the body during ejaculation. Because it wraps around the urethra, the first symptom that something might be awry is the inability to have a steady flow of urine. When the prostate is swollen with inflammation or a tumor is growing there, it can constrict the urethra in such a way that it affects the normal flow of urine. Your bladder may not feel like it is completely emptied, and no urine flows, though you still feel the urge to urinate.


It’s very important to see a doctor when symptoms first occur, to determine the degree of seriousness. There are less serious conditions, such as prostatitis (inflammation of the prostate) and Benign Prostatic Hyperplasia (enlargement of the prostate that is non-cancerous), that have similar symptoms to prostate cancer. Prompt attention could relieve painful symptoms quickly and help rule out a more serious root cause.


Prostate cancer occurs when the cells of the prostate gland multiply at an abnormal pace and do not undergo their normal rate of cell death. This can cause the gland to grow, create a tumor, and even clamp the flow of all fluids from the urethra. These abnormal cells can break off and invade nearby lymph nodes or travel to other parts of the body, including the spine and the brain. This is called “metastasis.”


Prostate Cancer Risk Factors and Statistics


Many factors increase the risk of having prostate cancer. While about 1 out of 8 men may receive a prostate cancer diagnosis in their lifetime, only about 1 in 41 will actually succumb and pass away from it. It is estimated that there will be 268,560 new prostate cancer cases diagnosed in the U.S. in 2022 (3). Roughly speaking, the odds are you won’t get prostate cancer, and if you do get it, odds are it won’t be fatal.


AGE

Age is a big factor, as most diagnoses happen in the mid-60s. It’s rare for a man younger than 40 to be diagnosed with prostate cancer, and most diagnoses happen in men over the age of 65, with the average age of diagnosis being about 66 years of age (4). While cancer isn’t the norm for the body, when it does occur, it’s often contained and eliminated by the immune system. However, as we age, the immune system may not catch and conquer all the overgrowths of cells.


FAMILY

Genetics is thought to play a role, as having a brother that is diagnosed with prostate cancer triples the risk, even more so than having a father with the diagnosis, which only doubles the risk (5). (Having multiple members of the family with a diagnosis increases risk as well.)


RACE

One’s race can make a difference in risk. For instance, African American men carry more risk than men of other races. When prostate cancer is found in African American men, it tends to be a later stage, more severe, and in younger men than in other races (6).


LIFESTYLE FACTORS

The American Cancer Society uses a rather neutral language in regard to lifestyle factors (diet, obesity, smoking) that contribute to prostate cancer risk by stating these are still being studied, with some studies showing correlations to higher risk, and others not. They do state that men who eat dairy are slightly more at risk for getting prostate cancer, as are firefighters who are exposed to toxic chemicals regularly.


As for obesity, heavier men have a lower risk of getting the slow-growing variety of prostate cancer but have a higher chance of getting the fast-growing variety (7). Meanwhile, more studies continue to pile up in medical journals showing correlations between lifestyle factors and prostate cancer risk. Admittedly, it’s hard to tease out a particular lifestyle factor and be able to prove that this factor alone contributes to prostate cancer when so many factors are occurring at the same time. Stress, poor diet, and the inflammation associated with obesity can all affect hormones, and hormones can influence cancer growth (8).


Symptoms of Prostate Cancer


Please do not hesitate to go see a doctor if anything out of the ordinary happens with your reproductive organs, even if it doesn’t make sense or seems to fall into a category of disease. Don’t let days, months, and years slide by while you suffer with something you know is out of the ordinary. This could be valuable time, and the stakes could be high. Many of the symptoms for non-serious ailments can overlap with cancer signals, so the symptoms may not indicate anything serious. However, for the very small number of people who would be found to have cancer, early intervention could save their lives. If you are in that small group, it suddenly matters very much. That said, here are the most common symptoms of prostate cancer (9, 10):


  • trouble urinating (slow, halting, or weak stream)

  • increased episodes of waking at night to urinate

  • difficulty achieving an erection

  • signs of blood in the semen or urine

  • unexplained bodily pain (for example, pain in the hips, back, chest)

  • numb or weak feet and/or legs

  • pain upon ejaculation or decreased amount of ejaculate

  • swelling or “bone pain” in the lower half of the body, especially if also experiencing issues with urinating, maintaining an erection, or ejaculating.


Testing for Prostate Cancer


PSA Blood Test

By far, the easiest test for prostate cancer is the Prostate-specific Antigen (PSA) blood test, which can be added to your usual blood tests during a physical. This test detects a protein in the blood that is made by the prostate, whether it is healthy or contains cancer. A high score can be an early warning signal that a situation is brewing. Typically, if a score is abnormally high or rises over 25% within a year (even within the normal range), it can signal a need for more investigation. There is some debate about the usefulness of PSA because it was originally designed to monitor men who had already been diagnosed with prostate cancer and its utility as a screening tool has been scrutinized in the medical literature. Using PSA screening testing is something that should be discussed with your physician prior to making a decision.


Statistically speaking, those with scores between 4.0 and 10.0 have about a 1 in 4 chance of having prostate cancer (11). One option is to start screening with annual physical exams beginning at about 50 years of age, or earlier if you are African American or have a family history of prostate cancer.


Other tests - There are other types of exams for detecting prostate issues, such as the “Digital Rectal Exam” (DRE) or an expanded PSA blood panel called the “4K.” The DRE can also be used to cause prostate cells to be released into the urine and then tested with a urine test to detect Prostate Cancer Antigen 3 (PCA3) or TMPRSS2:ERG (a genetic marker).


A biopsy or imaging may be an option, which may be suggested after positive PSA, 4K, or DRE results. Depending on your medical history, family history, and other factors, your doctor can suggest the best course of testing for you, including what age to start testing.


Prevention of Prostate Cancer


Please read our previous article on general cancer prevention to learn more about reducing risks for prostate cancer as well as other types of cancers. To recap, these strategies include supplementing with vitamin D, maintaining a healthy weight, exercising to the point of sweating daily if possible, and actively detoxifying.


In general, cancer finds it easy to survive in a low oxygen, high sugar (glucose) environment. Anything which boosts oxygen and reduces blood sugar will make conditions less favorable for cancer growth, including the simple acts of eating a low-sugar, nutritious diet and taking vigorous daily walks. Detoxifying the body is especially important, including strategies such as colon hydrotherapy and sauna therapy may be good options for detoxification, among other.


Supplements - Ensure that you are taking some supplements that help support a healthy prostate. Male reproductive organs benefit from zinc, selenium, and saw palmetto, as well as anti-inflammatory nutrients. There are many good blends to be found for the prostate as stand-alone supplements, but also can be found as additional ingredients in “men’s formulas” of multivitamins. Anything containing antioxidants, that boosts nitric oxide (NO2), or that is anti-inflammatory can assist in the reduction of cancer risk.


Selenium: Selenium boosts the power of antioxidants. Tissues can suffer “oxidative stress,” which damages DNA and make the cells vulnerable to cancer activity. Selenium combats oxidative stress, so it helps reduce conditions that are favorable to cancer (12). Between 50-100 mcg daily is good. Brazil nuts are high in selenium, and 2 -3 brazil nuts a day can help satisfy selenium needs.


Zinc: The prostate needs some zinc, but not too much. Zinc can help reduce inflammation in the prostate and appears to have some protective properties. Some zinc is taken in through the consumption of red meat, and the total daily intake should probably not exceed 100mg. A sufficient amount to fend off zinc deficiency is likely 40mg daily. If supplementing with zinc for long periods, please take a little copper, as zinc interferes with copper absorption. Having zinc levels checked is another important option.


Saw Palmetto: This supplement is derived from a plant and can slow the growth of prostate cancer and induce prostate cancer cell death (13). It can also reduce DHT, a metabolite of testosterone that, when a person gets too much, is thought to contribute to an enlarged prostate, hair loss, and loss of libido. Saw palmetto has been seen to reduce prostate inflammation. A good daily dose is 320mg.

Lycopene:The red pigment in tomatoes, lycopene is a cancer-fighting powerhouse. Not only can it help prevent cancer, but it can also slow the progression of cancer (14). It is better to get this from food, especially cooked, concentrated tomato sauce or red bell pepper sauce. However, there are lycopene supplements available as well. There is no established daily value of lycopene, though many quality supplements have around 5mg - 10mg as a daily dose.


Conventional Treatments


FDA-approved treatments for prostate cancer are surgery, chemotherapy, radiation, and hormone therapies (15). While a urologist may assist in the diagnosis of prostate cancer and may begin helping you with a slow-growing variety, an oncologist (cancer specialist) will be engaged if a fast-spreading cancer is detected. The oncologist will work with you to determine the best course of action to slow or stop the growth of cancer.


Complementary Medicine (Before, During, or After)


Since cancer finds high oxygen, low inflammation environments inhospitable, effective prevention and complementary therapies during cancer treatment and post-treatment are those that reduce oxidative stress, improve oxygenation, and are anti-inflammatory.


HIGH DOSE IV VITAMIN C - Vitamin C has proven itself to be an excellent antioxidant and can slow the growth of cancer through a variety of mechanisms (16). Through its generation of hydrogen peroxide, it can directly be toxic to cancer tumor cells while sparing normal cells. While not approved as a prostate cancer treatment, it is a superb companion during or post-cancer treatment or can be used as a prevention strategy.


IV OZONE - This intravenous therapy can greatly reduce chronic inflammation, which is thought to be a risk factor for an internal environment favorable for cancer growth. Ozone molecules have an extra oxygen atom that can help reduce inflammation but can also be donated towards the action of killing pathogens (viruses, fungi, bacteria) in the blood. Killing pathogens reduces the burden on the immune system, which allows it to divert more energy toward preventing or overcoming cancer growth. Additionally, this IV therapy can quench “oxidation stress,” preventing DNA damage that can lead to cancer. As a bonus, IV ozone therapy has been shown to stimulate the immune system, which can be beneficial in preventing or slowing cancer growth. For more details about this amazing complementary therapy, see our article entitled, “Can Using Ozone and UVB Therapy Aid Healing?”


Temecula Center for Integrative Medicine is here to support you in your cancer prevention or cancer recovery goal. We have practitioners who have a long history in cancer care, such as Dr. Maggie Gama. Dr. Gama excels at diagnosing “mystery illnesses,” as she has extensive training in the field of pathology, which focuses on the nature and cause of a disease, as well as its origin. This in-depth training, plus her caring nature enables her to expertly diagnose and compassionately guide a patient through the cancer experience. If you are having unusual symptoms, don’t wait. Let us help you sort it out.


 

Jonathan Vellinga, M.D.

Jonathan Vellinga, MD is an Internal Medicine practitioner with a broad interest in medicine. He graduated Summa cum laude from Weber State University in Clinical Laboratory Sciences and completed his medical degree from the Medical College of Wisconsin.​


Upon graduation from medical school, he completed his Internal Medicine residency at the University of Michigan. Dr. Vellinga is board-certified with the American Board of Internal Medicine and a member of the Institute for Functional Medicine.

info@tcimedicine.com

951-383-4333


 

Sources:

1. If you have prostate cancer [Internet]. American Cancer Society. [cited 2022Sep29]. Available from: https://www.cancer.org/cancer/prostate-cancer/if-you-have-prostate-cancer.html

2. How is prostate cancer treated? [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; 2022 [cited 2022Sep29]. Available from: https://www.cdc.gov/cancer/prostate/basic_info/treatment.htm

3. American Cancer Society: Cancer Facts & Statistics [Internet]. American Cancer Society | Cancer Facts & Statistics. [cited 2022Sep29]. Available from: https://cancerstatisticscenter.cancer.org/#!/

4. Key statistics for prostate cancer: Prostate cancer facts [Internet]. American Cancer Society. [cited 2022Sep29]. Available from: https://www.cancer.org/cancer/prostate-cancer/about/key-statistics.html

5. Wilson KM, Giovannucci EL, Mucci LA. Lifestyle and dietary factors in the prevention of lethal prostate cancer. Asian J Androl. 2012 May;14(3):365-74. doi: 10.1038/aja.2011.142. Epub 2012 Apr 16. PMID: 22504869; PMCID: PMC3720164.

6. Who is at risk for prostate cancer? [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; 2022 [cited 2022Sep29]. Available from: https://www.cdc.gov/cancer/prostate/basic_info/risk_factors.htm

7. Prostate cancer risk factors [Internet]. American Cancer Society. [cited 2022Sep29]. Available from: https://www.cancer.org/cancer/prostate-cancer/causes-risks-prevention/risk-factors.html

8. MD Anderson Cancer Center, Underferth D. Hormones and cancer: What's the link? [Internet]. MD Anderson Cancer Center. MD Anderson Cancer Center; 2019 [cited 2022Sep29]. Available from: https://www.mdanderson.org/publications/focused-on-health/hormones-and-cancer-whats-the-link.h30Z1591413.html

9. Prostate cancer signs and symptoms [Internet]. American Cancer Society. [cited 2022Sep29]. Available from: https://www.cancer.org/cancer/prostate-cancer/detection-diagnosis-staging/signs-symptoms.html

10. Prostate cancer symptoms [Internet]. Johns Hopkins Medicine. 2021 [cited 2022Sep29]. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/prostate-cancer/prostate-cancer-symptoms

11. Tests for prostate cancer: Prostate cancer diagnosis [Internet]. American Cancer Society. [cited 2022Sep29]. Available from: https://www.cancer.org/cancer/prostate-cancer/detection-diagnosis-staging/how-diagnosed.html

12. Zakeri N, kelishadi MR, Asbaghi O, Naeini F, Afsharfar M, Mirzadeh E, et al. Selenium supplementation and oxidative stress: A Review [Internet]. PharmaNutrition. Elsevier; 2021 [cited 2022Sep29]. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2213434421000141

13. Yang Y, Ikezoe T, Zheng Z, Taguchi H, Koeffler HP, Zhu WG. Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling. Int J Oncol. 2007 Sep;31(3):593-600. PMID: 17671686.

14. Assar EA, Vidalle MC, Chopra M, Hafizi S. Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells. Tumour Biol. 2016 Jul;37(7):9375-85. doi: 10.1007/s13277-016-4798-3. Epub 2016 Jan 16. PMID: 26779636.

15. Commissioner Oof the. Prostate cancer: Symptoms, tests, and treatments [Internet]. U.S. Food and Drug Administration. FDA; [cited 2022Sep29]. Available from: https://www.fda.gov/consumers/consumer-updates/prostate-cancer-symptoms-tests-and-treatments

16. Reang J, Sharma PC, Thakur VK, Majeed J. Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer. Biomolecules. 2021 Jul 31;11(8):1130. doi: 10.3390/biom11081130. PMID: 34439796; PMCID: PMC8392841.

Comments


bottom of page